What This Means for Patients Because the results of ER and PR testing can make a difference in a patient's treatment and chance of recurrence, it's important that these tests are accurate. Because the results are used to guide treatment, it's important that the results be accurate. Most of these cases are ER-positive, meaning that there are estrogen receptors on the surface of the cell that bind to estrogen. Get the facts on radiation and hormone therapy, among…. Breast Lump Removal Lumpectomy. You can either have part or all of the breast tissue removed.
Why is knowing hormone receptor status important?
Estrogen receptor-positive ER-positive breast cancer is the most common type of breast cancer diagnosed today. According to the American Cancer Society , about 2 out of every 3 cases of breast cancer are hormone receptor-positive. Most of these cases are ER-positive, meaning that there are estrogen receptors on the surface of the cell that bind to estrogen. This cancer typically responds to hormone therapy. Some of the decline in breast cancer mortality rates can be credited to the effectiveness of hormone therapy drugs prescribed to women with ER-positive breast cancer. Newer treatment options for ER-negative tumors are also improving prognosis and life expectancy.
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Breast cancer cells taken out during a biopsy or surgery will be tested to see if they have certain proteins that are estrogen or progesterone receptors. When the hormones estrogen and progesterone attach to these receptors, they fuel the cancer growth. Cancers are called hormone receptor-positive or hormone receptor-negative based on whether or not they have these receptors proteins. Knowing the hormone receptor status is important in deciding treatment options. Receptors are proteins in or on cells that can attach to certain substances in the blood.
Hormonal therapy, sometimes also called anti-estrogen therapy, works by lowering the amount of estrogen in the body or blocking estrogen from attaching to the breast cancer cells. You and your doctor will work together to decide which form of hormonal therapy is best in your situation. Topics you may discuss include: other features of the breast cancer, such as stage; other medical conditions you may have; whether or not you have been through menopause menstrual periods have stopped ; and your personal preferences. Other hormonal therapies may be used to treat advanced breast cancer that is hormone-receptor-positive and does not respond to the treatments listed above. Megace chemical name: megestrol is a form of progestin that suppresses the effects of estrogen on breast cancer cells. Halotestin chemical name: fluoxymesterone is an anabolic steroid that lowers the amount of estrogen in the body.